Sapiens: A Brief History of Humankind - Yuval Noah Harari Page 0,171

there must be a creator who thought out all biological details in advance. The biologists are right about the past, but the proponents of intelligent design might, ironically, be right about the future.

At the time of writing, the replacement of natural selection by intelligent design could happen in any of three ways: through biological engineering, cyborg engineering (cyborgs are beings that combine organic with non-organic parts) or the engineering of inorganic life.

Of Mice and Men

Biological engineering is deliberate human intervention on the biological level (e.g. implanting a gene) aimed at modifying an organisms shape, capabilities, needs or desires, in order to realize some preconceived cultural idea, such as the artistic predilections of Eduardo Kac.

There is nothing new about biological engineering, per se. People have been using it for millennia in order to reshape themselves and other organisms. A simple example is castration. Humans have been castrating bulls for perhaps 10,000 years in order to create oxen. Oxen are less aggressive, and are thus easier to train to pull ploughs. Humans also castrated their own young males to create soprano singers with enchanting voices and eunuchs who could safely be entrusted with overseeing the sultans harem.

But recent advances in our understanding of how organisms work, down to the cellular and nuclear levels, have opened up previously unimaginable possibilities. For instance, we can today not merely castrate a man, but also change his sex through surgical and hormonal treatments. But that’s not all. Consider the surprise, disgust and consternation that ensued when, in 1996, the following photograph appeared in newspapers and on television:

46. A mouse on whose back scientists grew an ‘ear’ made of cattle cartilage cells. It is an eerie echo of the lion-man statue from the Stadel Cave. Thirty thousand years ago, humans were already fantasising about combining different species. Today, they can actually produce such chimeras.

No, Photoshop was not involved. It’s an untouched photo of a real mouse on whose back scientists implanted cattle cartilage cells. The scientists were able to control the growth of the new tissue, shaping it in this case into something that looks like a human ear. The process may soon enable scientists to manufacture artificial ears, which could then be implanted in humans.1

Even more remarkable wonders can be performed with genetic engineering, which is why it raises a host of ethical, political and ideological issues. And it’s not just pious monotheists who object that man should not usurp God’s role. Many confirmed atheists are no less shocked by the idea that scientists are stepping into nature’s shoes. Animal-rights activists decry the suffering caused to lab animals in genetic engineering experiments, and to the farmyard animals that are engineered in complete disregard of their needs and desires. Human-rights activists are afraid that genetic engineering might be used to create supermen who will make serfs of the rest of us. Jeremiahs offer apocalyptic visions of bio-dictatorships that will clone fearless soldiers and obedient workers. The prevailing feeling is that too many opportunities are opening too quickly and that our ability to modify genes is outpacing our capacity for making wise and far-sighted use of the skill.

The result is that we’re at present using only a fraction of the potential of genetic engineering. Most of the organisms now being engineered are those with the weakest political lobbies – plants, fungi, bacteria and insects. For example, lines of E. coli, a bacterium that lives symbiotically in the human gut (and which makes headlines when it gets out of the gut and causes deadly infections), have been genetically engineered to produce biofuel.2 E. coli and several species of fungi have also been engineered to produce insulin, thereby lowering the cost of diabetes treatment.3 A gene extracted from an Arctic fish has been inserted into potatoes, making the plants more frost-resistant.4

A few mammals have also been subject to genetic engineering. Every year the dairy industry suffers billions of dollars in damages due to mastitis, a disease that strikes dairy-cow udders. Scientists are currently experimenting with genetically engineered cows whose milk contains lysostaphin, a biochemical that attacks the bacteria responsible for the disease.5 The pork industry, which has suffered from falling sales because consumers are wary of the unhealthy fats in ham and bacon, has hopes for a still-experimental line of pigs implanted with genetic material from a worm. The new genes cause the pigs to turn bad omega 6 fatty acid into its healthy cousin, omega 3.6

The next generation of genetic engineering will make pigs with good fat look like