The Gene: An Intimate History - Siddhartha Mukherjee Page 0,261

Canadian Medical Association Journal 164, no. 11 (2001): 1612.

In 1993, when Gelsinger was: For details of the Jesse Gelsinger story see Evelyn B. Kelly, Gene Therapy (Westport, CT: Greenwood Press, 2007); Lyon and Gorner, Altered Fates; and Sally Lehrman, “Virus treatment questioned after gene therapy death,” Nature 401, no. 6753 (1999): 517–18.

By noon, the procedure was done: James M. Wilson, “Lessons learned from the gene therapy trial for ornithine transcarbamylase deficiency,” Molecular Genetics and Metabolism 96, no. 4 (2009): 151–57.

“How could such a beautiful thing”: Paul Gelsinger, author interview, November 2014 and April 2015.

That Wilson had a financial stake in: Robin Fretwell Wilson, “Death of Jesse Gelsinger: New evidence of the influence of money and prestige in human research,” American Journal of Law and Medicine 36 (2010): 295.

In January 2000, when the FDA inspected: Sibbald, “Death but one unintended consequence,” 1612.

“The entire field of gene therapy”: Carl Zimmer, “Gene therapy emerges from disgrace to be the next big thing, again,” Wired, August 13, 2013.

“Gene therapy is not yet therapy”: Sheryl Gay Stolberg, “The biotech death of Jesse Gelsinger,” New York Times, November 27, 1999, nytimes/1999/11/28/magazine/the-biotech-death-of-jesse-gelsinger.html.

“cautionary tale of scientific overreach”: Zimmer, “Gene therapy emerges.”

Genetic Diagnosis: “Previvors”

All that man is: W. B. Yeats, The Collected Poems of W. B. Yeats, ed. Richard Finneran (New York: Simon & Schuster, 1996), “Byzantium,” 248.

The anti-determinists want to say: Jim Kozubek, “The birth of ‘transhumans,’ ” Providence (RI) Journal, September 29, 2013.

“Genetic tests,” as Eric Topol: Eric Topol, author interview, 2013.

Between 1978 and 1988, King added: Mary-Claire King, “Using pedigrees in the hunt for BRCA1,” DNA Learning Center, dnalc.org/view/15126-Using-pedigress-in-the-hunt-for-BRCA1-Mary-Claire-King.html.

she had pinpointed it to a region: Jeff M. Hall et al., “Linkage of early-onset familial breast cancer to chromosome 17q21,” Science 250, no. 4988 (1990): 1684–89.

“Being comfortable with uncertainty”: Jane Gitschier, “Evidence is evidence: An interview with Mary-Claire King,” PLOS, September 26, 2013.

In 1998, Myriad was granted: E. Richard Gold and Julia Carbone, “Myriad Genetics: In the eye of the policy storm,” Genetics in Medicine 12 (2010): S39–S70.

“Some of these women [with BRCA1 mutations]”: Masha Gessen, Blood Matters: From BRCA1 to Designer Babies, How the World and I Found Ourselves in the Future of the Gene (Boston: Houghton Mifflin Harcourt, 2009), 8.

In 1908, the Swiss German psychiatrist: Eugen Bleuler and Carl Gustav Jung, “Komplexe und Krankheitsursachen bei Dementia praecox,” Zentralblatt für Nervenheilkunde und Psychiatrie 31 (1908): 220–27.

In the 1970s, studies demonstrated: Susan Folstein and Michael Rutte, “Infantile autism: A genetic study of 21 twin pairs,” Journal of Child Psychology and Psychiatry 18, no. 4 (1977): 297–321.

“domineering, nagging and hostile mother”: Silvano Arieti and Eugene B. Brody, Adult Clinical Psychiatry (New York: Basic Books, 1974), 553.

National Book Award for science: “1975: Interpretation of Schizophrenia by Silvano Arieti,” National Book Award Winners: 1950–2014, National Book Foundation, nationalbook.org/nbawinners_category.html#.vcnit7fxhom.

In 2013, an enormous study identified: Menachem Fromer et al., “De novo mutations in schizophrenia implicate synaptic networks,” Nature 506, no. 7487 (2014): 179–84.

108 genes (or rather genetic regions): Schizophrenia Working Group of the Psychiatric Genomics, Nature 511 (2014): 421–27.

The strongest, and most: “Schizophrenia risk from complex variation of complement component 4,” Sekar et al. Nature 530, 177–183.

“There are lots of”: Benjamin Neale, quoted in Simon Makin, “Massive study reveals schizophrenia’s genetic roots: The largest-ever genetic study of mental illness reveals a complex set of factors,” Scientific American, November 1, 2014.

“We of the craft are all crazy”: Carey’s Library of Choice Literature, vol. 2 (Philadelphia: E. L. Carey & A. Hart, 1836), 458.

In Touched with Fire, an authoritative: Kay Redfield Jamison, Touched with Fire (New York: Simon & Schuster, 1996).

Hans Asperger, the psychologist who first: Tony Attwood, The Complete Guide to Asperger’s Syndrome (London: Jessica Kingsley, 2006).

As Edvard Munch put it: Adrienne Sussman, “Mental illness and creativity: A neurological view of the ‘tortured artist,’ ” Stanford Journal of Neuroscience 1, no. 1 (2007): 21–24.

illness as the “night-side of life”: Susan Sontag, Illness as Metaphor and AIDS and Its Metaphors (New York: Macmillan, 2001).

Entitled “The Future of Genomic Medicine”: Details of the conference can be found in “The future of genomic medicine VI,” Scripps Translational Science Institute, slideshare.net/mdconferencefinder/the-future-of-genomic-medicine-vi-23895019; Eryne Brown, “Gene mutation didn’t slow down high school senior,” Los Angeles Times, July 5, 2015, latimes/local/california/la-me-lilly-grossman-update-20150702-story.html; and Konrad J. Karczewski, “The future of genomic medicine is here,” Genome Biology 14, no. 3 (2013): 304.

Alexis and Noah Beery: “Genome maps solve medical mystery for California twins,” National Public Radio broadcast, June 16, 2011.

Based on that genetic diagnosis: Matthew N. Bainbridge et al., “Whole-genome sequencing for optimized patient management,” Science Translational Medicine 3, no. 87 (2011): 87re3.

That a mutation